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Review
. 2019 Nov;10(6):e1547.
doi: 10.1002/wrna.1547. Epub 2019 May 29.

mRNA methylation in cell senescence

Gabriel Casella  1 , Dimitrios Tsitsipatis  1 , Kotb Abdelmohsen  1 , Myriam Gorospe  1
Affiliations
Review

mRNA methylation in cell senescence

Gabriel Casella et al. Wiley Interdiscip Rev RNA. 2019 Nov.

Abstract

Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post-transcriptional level. This regulation involves the interaction of RNA-binding proteins and noncoding RNAs with senescence-associated messenger RNAs (mRNAs). There is increasing evidence that these associations are modulated by chemical modifications of specific mRNA nucleotides which can enhance or reduce the binding of regulatory factors. Recent technological advances in mass spectrometry, next-generation sequencing, and genome mapping have improved markedly the detection of mRNA modifications. Given the rising interest in the epitranscriptomic control of gene expression in aging, we discuss our incipient understanding of the chemical mRNA modifications, specifically m6 A and m5 C, that influence cellular senescence. This article is categorized under: RNA Export and Localization > RNA Localization RNA Processing > RNA Editing and Modification.

Keywords: 5-methylcytosine; N6-methyladenosine; aging; mRNA modifications; senescence.

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Figures

FIGURE 1
FIGURE 1
Senescence-associated changes in m6A and m5C modifications. The main modifications reported in mRNAs encoding senescence-associated proteins, m6A and m5C, are indicated (gray rectangles). Each modification can promote (green) or repress (purple) protein expression from the respective mRNAs. *mRNA methylation at m6A and m5C decreases as cells progress towards senescence. mRNA, messenger RNA
See this image and copyright information in PMC

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