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Observational Study
. 2019 Aug;20(8):421-426.
doi: 10.1111/1751-2980.12793. Epub 2019 Jul 3.

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi-center, observational, prospective and cohort study

Chuan Han  1   2 , Zhen Ni  1   3 , Ting Yuan  1   4 , Jian Zhang  1 , Chan Wang  5 , Xin Wang  6 , Han Bing Ning  7 , Jie Liu  1 , Nina Sun  8 , Cai Fang Liu  8 , Miao Shi  8 , Wen Quan Lu  7 , Yong Quan Shi  1
Affiliations
Observational Study

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi-center, observational, prospective and cohort study

Chuan Han et al. J Dig Dis. 2019 Aug.

Abstract

Objectives: This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates.

Methods: A multicenter observational prospective cohort study was conducted. A total of 496 H. pylori- positive (H. pylori+ ) and 257 H. pylori-negative (H. pylori- ) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a 13 C-urea breath test (UBT) was performed for all the participants. The H. pylori+ patients were divided into two subgroups based on their serum vitamin D levels (<10 or ≥10 ng/mL). A second 13 C-UBT was performed between 4 and 8 weeks after 14-day bismuth-containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey.

Results: Serum vitamin D levels were significantly lower in the H. pylori+ group than in the H. pylori- group ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of <10 ng/mL and ≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183-0.791, P = 0.010).

Conclusions: Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.

Keywords: Helicobacter pylori; eradication; infection; vitamin D.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Flowchart of participant selection and grouping. H. pylori, Helicobacter pylori
See this image and copyright information in PMC

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