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Observational Study
. 2019 May 30;20(1):193.
doi: 10.1186/s12882-019-1389-8.

Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases

Consuelo Pedrós  1   2 , Mónica Ávila  3 , Ainhoa Gómez-Lumbreras  4   5 , Marcela Manríquez  2 , Rosa Morros  4   6   7 ; ALIMAR-C2 Study Group
Collaborators, Affiliations
Observational Study

Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases

Consuelo Pedrós et al. BMC Nephrol. .

Abstract

Background: The use of metformin in patients with type 2 diabetes mellitus has been associated with lactic acidosis. However, the information available in patients with moderate-severe chronic kidney disease is scarce.

Methods: The ALIMAR-C2 study is a case-control study to assess the association between metformin and lactic acidosis in patients with type 2 diabetes mellitus and moderate-severe chronic kidney disease. The study will be performed with computerized registered electronic health records from eight Spanish hospitals linked to their corresponding primary care health areas from 2010 to 2016, comprising approximately 22.1 million person-years of follow-up. Logistic regression will be used to assess the crude and adjusted risk of lactic acidosis associated with metformin use overall and stratifying by use and dose categories, and chronic kidney disease stage. The overall case fatality rate of lactic acidosis, as well as the case fatality rate stratified by chronic kidney disease stage, will be calculated.

Discussion: The ALIMAR-C2 study will provide useful information about the risk of lactic acidosis in type 2 diabetes mellitus patients with renal impairment using metformin.

Keywords: Case-control studies; Chronic kidney failure; Electronic health records; Lactic acidosis; Metformin; Type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare that they have no competing interests.

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