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. 2019 Jan-Mar;-5(1):102-106.
doi: 10.4183/aeb.2019.102.

HYPOVITAMINOSIS D IN HIV-INFECTED PATIENTS

C Poiana  1   2 , C Capatina  1   2 , Anca Streinu Cercel  3   4 , O Sandulescu  3   4 , A Streinu Cercel  3   4
Affiliations

HYPOVITAMINOSIS D IN HIV-INFECTED PATIENTS

C Poiana et al. Acta Endocrinol (Buchar). 2019 Jan-Mar.

Abstract

Introduction: Vitamin D (VD) deficiency is highly prevalent worldwide.

Aim: To assess the prevalence of hypovitaminosis D in HIV-positive Romanian patients compared to controls.

Methods: Serum 25OHD concentration was measured in HIV-infected patients and a control sample, matched by age, sex and menopausal status. The 25OHD status was defined as: deficiency < 20 ng/mL (severe deficiency <10 ng/mL), insufficiency 20-30 ng/mL, normal >30 ng/mL.

Results: We evaluated 118 HIV-positive patients (72 males, 46 females), aged 36.9±12.2 years. 98.14% of them were on complex antiviral regimens. The B/C hepatitis coinfection rate was 9.3%. The control sample consisted of 119 subjects, (74 males, 45 women). The median and interquartile range for serum 25OHD concentration in patients was 17.6 (9.7, 26.9) ng/mL and 23.7 (18.4, 27.5) ng/mL in controls (p=0.001). Only 15.96% of HIV-positive cases and 12.71% of controls had normal VD status. The percentage of cases with severe VD deficiency was significantly higher in HIV positive cases (23.52%) compared to HIV-negative controls (4.2%, p=0.001).

Conclusions: Hypovitaminosis D was identified in 84.04% of HIV-infected patients, but the serum 25OHD concentration was not associated with specific HIV-related factors in our sample. Clinical guidelines regarding VD status determination and supplementation in HIV patients are needed.

Keywords: HIV-infection; deficiency; vitamin D.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1.
Figure 1.
Distribution of serum 25OHD concentration in the study group and the control group.
Figure 2.
Figure 2.
The VD status in the study group compared with the control group.
See this image and copyright information in PMC

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