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. 2017 Apr-Jun;13(2):138-143.
doi: 10.4183/aeb.2017.138.

SERUM OMENTIN-1 LEVELS AND ENDOTHELIAL DYSFUNCTION IN OBESITY

A R Çimen  1 , E T Cerit  1 , O T Iyidir  1 , R Karakus  2 , B B Uyar  3 , F B Toruner  1 , N Cakir  1 , M Arslan  1
Affiliations

SERUM OMENTIN-1 LEVELS AND ENDOTHELIAL DYSFUNCTION IN OBESITY

A R Çimen et al. Acta Endocrinol (Buchar). 2017 Apr-Jun.

Abstract

Introduction: Our aim was to investigate the relationship between serum omentin-1 levels and endothelial dysfunction in obese patients.

Material and methods: We evaluated 50 obese patients, and age/gender matched 45 healthy non-obese subjects as controls. Oral glucose tolerance test, lipid parameters, uric acid levels, homeostatic model assessment-insulin resistance (HOMA-IR) index, serum omentin-1 levels and flow mediated dilatation (FMD) % were measured in all subjects. Body compositions were analyzed with bioelectrical impedance method using a Tanita Body Composition Analyzer and ViScan.

Results: Serum omentin-1 levels were found significantly lower in obese population compared to the control subjects. FMD response was significantly decreased in obese population. There was a significant positive correlation between serum omentin-1 levels and FMD response (r=0.359, p<0.001). Serum omentin-1 levels were negatively correlated with body mass index (BMI), waist circumference, total fat percentage, visceral fat, fasting insulin and HOMA-IR index.

Conclusion: Lower serum omentin-1 levels and decreased FMD response may be an early marker of endothelial dysfunction in obese patients.

Keywords: Endothelial Dysfunction; Flow Mediated Dilatation; Obesity; Omentin-1.

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Conflict of interest statement

The authors declare that they have no conflict of interest concerning this article.

Figures

Figure 1.
Figure 1.
(A) Correlation between Omentin-1 and FMD (r=0.359, p<0.001), (B) Correlation between Omentin-1 and HOMA-IR score (r=-0.304, p=0.005).
Figure 2.
Figure 2.
(A) Correlation between FMD and BMI (r=-0.678, p<0.001); (B) Correlation between FMD and HOMA-IR score (r=-0.648, p<0.001); (C) Correlation between FMD and ViScan Visceral Fat (r=-0.677, p<0.001). FMD= Flow mediated dilatation. BMI= Body mass index. HOMA-IR= homeostatic model assessment-insulin resistance.
See this image and copyright information in PMC

References

    1. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010;316:129–139. - PubMed
    1. Ohashi K, Shibata R, Murohara T, Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol Metab. 2014;25:348–355. - PubMed
    1. Ghoorah K, Campbell P, Kent A, Maznyczka A, Kunadian V. Obesity and cardiovascular outcomes: a review. Eur Heart J Acute Cardiovasc Care. 2016;5(1):77–85. - PubMed
    1. Nakamura K, Fuster JJ, Walsh K. Adipokines: a link between obesity and cardiovascular disease. J Cardiol. 2014;63:250–259. - PMC - PubMed
    1. Barth S, Klein P, Horbach T, Dötsch J, Rauh M, Rascher W, Knerr I. Expression of neuropeptide Y, omentin and visfatin in visceral and subcutaneous adipose tissues in humans: relation to endocrine and clinical parameters. Obes Facts. 2010;3:245–251. - PMC - PubMed

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