Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Apr-Jun;14(2):261-267.
doi: 10.4183/aeb.2018.261.

TG/HDL-C RATIO AS CARDIO-METABOLIC BIOMARKER EVEN IN NORMAL WEIGHT WOMEN

G Borrayo  1 , L Basurto  2 , E González-Escudero  2   3 , A Diaz  2 , A Vázquez  2 , L Sánchez  3 , G O Hernández-González  3 , S Barrera  4 , J A Degollado  5 , N Córdova  2 , F Avelar  5
Affiliations
Case Reports

TG/HDL-C RATIO AS CARDIO-METABOLIC BIOMARKER EVEN IN NORMAL WEIGHT WOMEN

G Borrayo et al. Acta Endocrinol (Buchar). 2018 Apr-Jun.

Abstract

Context: Despite that the Triglycerides/High Density Lipoprotein Cholesterol (TG/HDL-C) ratio has been associated with insulin resistance and cardiovascular disease, some outcomes differ between populations.

Objective: The objective of this study was to evaluate the association between TG/HDL-C ratio and cardio-metabolic risk factors in both obese and normal weight women.

Design: Cross sectional, from January to December of 2015.

Subjects and methods: Two hundred and fifty three women aged 40 to 60 years. Anthropometric and laboratory measurements were performed. Insulin resistance was measured by the homeostasis model assessment for insulin resistance (HOMA-IR). All participants underwent a Doppler ultrasound to measure intima-media thickness of carotid artery (cIMT).

Results: TG/HDL-C ratio correlated with body mass index (r=0.194, p=0.01), and visceral adipose tissue (r=0.193, p=0.002). Additionally, TG/HDL-C correlated with glucose (r=0.367, p=0.001), insulin (r=0.354, p=0.001) and HOMA-IR (r=0.396 p=0.001). TG/HDL-C was associated with prediabetes, Odds Ratio (OR) was 1.83 (95%CI 1.07-3.13) and insulin resistance 3.27 (95%CI 1.78-6.01), and this risk remains in normal weight women 4.7 (95%CI 1.2-17.81) for prediabetes and 4.38 (95%CI 1.42-13.84) for insulin resistance. No significant risk for cIMT.

Conclusion: A TG/HDL-C ratio ≥ 3.0 is a potential risk factor for prediabetes and insulin resistance in women 40-60 years, even in normal weight women.

Keywords: Carotid Intima-Media Thickness; Insulin Resistance; Prediabetes; TG/HDL-C.

PubMed Disclaimer

Conflict of interest statement

Authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Forest Plot using association by Odds Ratio (OR) of cardiometabolic risk factors among three groups 1) All women with TG/HDL ratio ≥ 3.0, 2) Women with overweight and obesity and 3) Women with normal BMI and TG/HDL-C ratio ≥ 3.0. cIMT: Carotid intima-media thickness.
See this image and copyright information in PMC

References

    1. Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197–1209. - PubMed
    1. Rojas-Martínez R1, Aguilar-Salinas CA, Jiménez-Corona A, Gómez-Pérez FJ, Barquera S, Lazcano-Ponce E. Prevalence of obesity and metabolic syndrome components in Mexican adults without type 2 diabetes or hypertension. Salud Publica Mex. 2012;54(1):7–12. - PubMed
    1. INEGI Causas de Mortalidad, Defunciones generales de mujeres por principales causas de mortalidad, 2013 2015 [cited 2015 10/September/2015]. Available from: http://www3.inegi.org.mx/sistemas/sisept/Default.aspx?t=mdemo125&s=est&c....
    1. Sims EA. Are there persons who are obese but metabolically healthy? 2001;50(12):1499–1504. - PubMed
    1. Shaharyar S, Roberson LL, Jamal O, Younus A, Blaha MJ, Ali SS, Zide K, Agatston AA, Blumenthal RS, Conceição RD, Santos RD, Nasir K. Obesity and metabolic phenotypes (metabolically healthy and unhealthy variants) are significantly associated with prevalence of elevated C-reactive protein and hepatic steatosis in a large healthy Brazilian population. J Obes. 2015;2015:178526. - PMC - PubMed

Publication types

LinkOut - more resources