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Case Reports
. 2017 Feb 23;6(2):65-69.
doi: 10.1007/s13691-016-0275-5. eCollection 2017 Apr.

Concurrent high-grade serous carcinoma and borderline tumor demonstrating different chemo-sensitivity

Momoko Inoue  1 , Masataka Takenaka  1 , Masaharu Fukunaga  2 , Seiji Isonishi  1
Affiliations
Case Reports

Concurrent high-grade serous carcinoma and borderline tumor demonstrating different chemo-sensitivity

Momoko Inoue et al. Int Cancer Conf J. .

Abstract

Ovarian high-grade serous adenocarcinoma responds well to regular platinum/taxane chemotherapy, while borderline tumor survives and demonstrates persistent disease. A 69-year-old Japanese woman was suspected for having advanced ovarian carcinoma. MRI showed cystic tumor containing solid component of the right adnexal region with massive ascites and peritoneal dissemination. Serum CA125 was elevated to 203 µ/ml; however, no remote metastases were detected. Laparotomy revealed that peritoneal carcinomatosis spreads out to omentum and subphrenic area. Omentum was partially removed with big tumor nodules that histologically demonstrated the high-grade serous adenocarcinoma with positive ascites cytology. After 6 cycles of postoperative chemotherapy with docetaxel and carboplatin, she received second surgery where the known residual bilateral adnexa and all of the persistent tumors were perfectly resected. Pathological examination of the tumor revealed serous borderline tumor with microinvasion and no evidence of residual high-grade serous carcinoma with negative ascites cytology. This is the extremely rare case of concurrent high-grade serous carcinoma and borderline tumor demonstrating differential chemo-sensitivity.

Keywords: Chemo-sensitivity; High-grade serous carcinoma; Serous borderline tumor.

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Conflict of interest statement

The authors report no conflicts of interest.This patient has already died of disease more than a year ago. At this moment, we could not keep track of the patient’s guardian or next of kin and the written consent could not be available. In the report described here, all personal details of the patient were removed from the case report to ensure that the patient cannot be identified.

Figures

Fig. 1
Fig. 1
Sagittal (a) and axial (b) MR image of the pelvis showed double cystic masses in the pelvic cavity containing solid component with high intensity. c Post-chemotherapy CAT scan revealed persisting small cystic mass in subphrenic area (arrow)
Fig. 2
Fig. 2
a Primary tumor shows high-grade serous carcinoma composed of cells with enlarged atypical nuclei and abundant mitotic figures. b The persistent tumor shows serous borderline tumor composed of uniform small tumor cells without mitotic figure
Fig. 3
Fig. 3
Immunohistochemical staining. P53 staining was shown in primary tumor (a), persistent tumor (b), and p53 negative control (c). MIB-1 staining was shown in primary tumor (d) and persistent tumor (e)
See this image and copyright information in PMC

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