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Randomized Controlled Trial
. 2020 Jan 16;70(3):525-527.
doi: 10.1093/cid/ciz455.

Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Catherine E Oldenburg  1   2   3 , Armin Hinterwirth  1 , Ali Sié  4 , Boubacar Coulibaly  4 , Lucienne Ouermi  4 , Clarisse Dah  4 , Charlemagne Tapsoba  4 , Susie L Cummings  1 , Lina Zhong  1 , Cindi Chen  1 , Samarpita Sarkar  1 , Till Bärnighausen  5   6   7 , Thomas M Lietman  1   2   3 , Jeremy D Keenan  1   2 , Thuy Doan  1   2
Affiliations
Randomized Controlled Trial

Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Catherine E Oldenburg et al. Clin Infect Dis. .

Erratum in

Abstract

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

Keywords: antimicrobial resistance; randomized controlled trial; resistome.

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Figures

Figure 1.
Figure 1.
Box plot of Chao1 richness of resistance genes by antibiotic arm. Individual points represent individual samples.
See this image and copyright information in PMC

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