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Meta-Analysis
. 2019 May 31;19(1):527.
doi: 10.1186/s12885-019-5748-4.

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed  1 , Fatemeh Varse  2 , Hamid Reza Baradaran  3   4 , Yousef Moradi  5 , Sorour Khateri  6 , Emilie Friberg  7 , Zaher Khazaei  8 , Saeedeh Gharahjeh  9 , Shahrzad Tehrani  10 , Amir-Babak Sioofy-Khojine  11 , Zahra Najmi  12
Affiliations
Meta-Analysis

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed et al. BMC Cancer. .

Abstract

Background: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.

Methods: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.

Results: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).

Conclusions: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

Keywords: Diabetes; Endometrial Cancer; Meta-analysis; Risk.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow Diagram of the Literature Searches and Study Selection
Fig. 2
Fig. 2
Association between Diabetes and Risk of Endometrial Cancer
Fig. 3
Fig. 3
Association between Diabetes and Risk of Endometrial Cancer by Type of Study
See this image and copyright information in PMC

References

    1. Lortet-Tieulent J, et al. International patterns and trends in endometrial cancer incidence, 1978–2013. J Natl Cancer Inst. 2017;110(4):354–361. doi: 10.1093/jnci/djx214. - DOI - PubMed
    1. Stroup DF, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Jama. 2000;283(15):2008–2012. doi: 10.1001/jama.283.15.2008. - DOI - PubMed
    1. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49(1):33–64. doi: 10.3322/canjclin.49.1.33. - DOI - PubMed
    1. Luo J, et al. Association between diabetes, diabetes treatment and risk of developing endometrial cancer. Br J Cancer. 2014;111(7):1432. doi: 10.1038/bjc.2014.407. - DOI - PMC - PubMed
    1. Anderson KE, et al. Diabetes and endometrial cancer in the Iowa women’s health study. Cancer Epidemiol Biomarkers Prev. 2001;10(6):611–616. - PubMed