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. 2019 May 31;20(1):199.
doi: 10.1186/s12882-019-1392-0.

Risk factors for catheter-related infections in patients receiving permanent dialysis catheter

Fani Delistefani  1 , Manuel Wallbach  1 , Gerhard A Müller  1 , Michael J Koziolek  2 , Clemens Grupp  1   3
Affiliations

Risk factors for catheter-related infections in patients receiving permanent dialysis catheter

Fani Delistefani et al. BMC Nephrol. .

Abstract

Background: Due to rising vascular comorbidities of patients undergoing dialysis, the prevalence of permanent hemodialysis catheters as hemodialysis access is increasing. However, infection is a major complication of these catheters. Therefore, identification of potential predicting risk factors leading to early infection related complications is valuable, in particular the significance the CRP (C-reactive protein)-value is of interest.

Methods: In this retrospective study 151 permanent hemodialysis catheters implanted in 130 patients were examined. The following data were collected at the time of catheter implantation: CRP-value, history of catheter-related infection, microbiological status, immunosuppression and diabetes mellitus. The primary outcomes were recorded over the 3 months following the implantation: catheter-related infection, days of hospital stay and death. Catheter removal or revision, rehospitalization and use of antibiotics were identified as secondary outcomes.

Results: We identified a total of 27 (17.9%) infections (systemic infection: 2.26 episodes/ 1000 catheter days, local infection: 0.6 episodes/ 1000 catheter days). The development of an infection was independent of the CRP-value (p = 0.66) as well as the presence of diabetes mellitus (p = 0.64) or immunosuppression (p = 0.71). Univariate analysis revealed that infection was more frequent in patients with MRSA-carriage (p < 0.001), in case of previous catheter-related infection (p < 0.05) and of bacteremia or bacteriuria in the period of 3 months before catheter implantation (p < 0.001). Catheter removal or revision (p = 0.002), rehospitalization (p = 0.001) and use of antibiotics (p = 0.02) were also more often observed in patients with MRSA-carriage.

Conclusions: The CRP-value at the time of implantation of a permanent hemodialysis catheter is not associated with the development of early catheter related infections, but an individual history of catheter-related infection, MRSA-carriage and bacteremia or bacteriuria in the period of 3 months prior to catheter implantation are significant risk factors.

Keywords: CRP; Catheter related complication; Germ carriage; Hemodialysis; MRSA; Tunneled catheter.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
There was no significant difference between the medians of initial CRP values of patients without (0), local (1) and systemic (2) infection within 3 months after catheter implantation (P = 0.15)
See this image and copyright information in PMC

References

    1. Malas MB, Canner JK, Hicks CW, Arhuidese IJ, Zarkowsky DS, Qazi U, Schneider EB, Black JH, 3rd, Segev DL, Freischlag JA. Trends in incident hemodialysis access and mortality. JAMA Surg. 2015;150(5):441–448. doi: 10.1001/jamasurg.2014.3484. - DOI - PubMed
    1. Thomson P, Stirling C, Traynor J, Morris S, Mactier R. A prospective observational study of catheter-related bacteraemia and thrombosis in a haemodialysis cohort: univariate and multivariate analyses of risk association. Nephrol Dial Transplant. 2010;25(5):1596–1604. doi: 10.1093/ndt/gfp667. - DOI - PubMed
    1. Ethier J, Mendelssohn DC, Elder SJ, Hasegawa T, Akizawa T, Akiba T, Canaud BJ, Pisoni RL. Vascular access use and outcomes: an international perspective from the dialysis outcomes and practice patterns study. Nephrol Dial Transpl. 2008;23(10):3219–3226. doi: 10.1093/ndt/gfn261. - DOI - PMC - PubMed
    1. Silva TN, Mendes ML, Abrao JM, Caramori JT, Ponce D. Successful prevention of tunneled central catheter infection by antibiotic lock therapy using cefazolin and gentamicin. Int Urol Nephrol. 2013;45(5):1405–1413. doi: 10.1007/s11255-012-0339-1. - DOI - PubMed
    1. Moss AH, Vasilakis C, Holley JL, Foulks CJ, Pillai K, Mcdowell DE. Use of a silicone dual-lumen catheter with a Dacron cuff as a long-term vascular access for hemodialysis-patients. Am J Kidney Dis. 1990;16(3):211–215. doi: 10.1016/S0272-6386(12)81020-1. - DOI - PubMed

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