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Editorial
. 2019 Jun;104(6):1098-1100.
doi: 10.3324/haematol.2018.213397.

Another piece of the puzzle added to understand t(4;11) leukemia better

Rolf Marschalek  1
Affiliations
Editorial

Another piece of the puzzle added to understand t(4;11) leukemia better

Rolf Marschalek. Haematologica. 2019 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
Proposed fuctions of both t(4;11) fusion proteins. MLL-AF4 binds to Menin1/LEDGF and SL1 to target gene promotors and strongly activate gene transcription, while AF4-MLL overwrites transcriptional elongation control and strongly activates chromatin within a very short time window. Patients who express both fusions diplay HOXA gene signatures and have a better outcome, while patients who either do not express AF4-MLL or actively repress it, usually activate the homeobox proteins IRX1/2. Expression of both proteins has been correlated with a worse outcome (IRX1/2 strongly activate EGR1-3 and HOXB4).
See this image and copyright information in PMC

Comment on

References

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