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Editorial
. 2019 Jun;104(6):1103-1105.
doi: 10.3324/haematol.2018.214908.

Is the mysterious platelet receptor GPV an unsuspected major target for platelet autoantibodies?

Paquita Nurden  1 , Alan T Nurden  1
Affiliations
Editorial

Is the mysterious platelet receptor GPV an unsuspected major target for platelet autoantibodies?

Paquita Nurden et al. Haematologica. 2019 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
GPV, a major target for autoantibodies in immune thrombocytopenia (ITP). (Left) Representation of a platelet showing the two principal receptor targets for platelet autoantibodies. Vollenberg et al., while confirming the abundance of autoantibodies detected by direct MAIPA in a series of 343 positive samples from among 1140 tested ITP patients, also showed a significant presence of antibodies to GPV. (Middle) The GPIb-IX-V complex showing the presence of anti-GPV antibody and highlighting binding or cleavage sites for thrombin and metalloproteases ADAM10 and ADAM17. Vollenberg et al. raise questions as to the consequences of bound autoantibodies on GPV structure, the cleavage of released soluble forms, and a potential desialylation of the subunits on platelet survival in ITP. (Right) The detection of both high avidity autoantibodies to GPV by MAIPA and additional low avidity antibodies by surface plasmon resonance (SPR) technology is intriguing, as both of these appear to contribute to the diagnosis of ITP.
See this image and copyright information in PMC

Comment on

References

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