Review

. 2019 May 31;19(7):41.

doi: 10.1007/s11892-019-1157-y.

Physical Activity in the Prevention of Development and Progression of Kidney Disease in Type 1 Diabetes

Drazenka Pongrac Barlovic^{1

2

3

4

5}, Heidi Tikkanen-Dolenc^{3

4

5}, Per-Henrik Groop^{6

7

8

9}

Affiliations

¹ University Medical Center Ljubljana, Ljubljana, Slovenia.
² Faculty of Medicine, University Ljubljana, Ljubljana, Slovenia.
³ Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O Box 63, FIN-00014, Helsinki, Finland.
⁴ Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
⁵ Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
⁶ Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O Box 63, FIN-00014, Helsinki, Finland. per-henrik.groop@helsinki.fi.
⁷ Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. per-henrik.groop@helsinki.fi.
⁸ Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. per-henrik.groop@helsinki.fi.
⁹ Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia. per-henrik.groop@helsinki.fi.

PMID: 31152254
PMCID: PMC6544601
DOI: 10.1007/s11892-019-1157-y

Review

Physical Activity in the Prevention of Development and Progression of Kidney Disease in Type 1 Diabetes

Drazenka Pongrac Barlovic et al. Curr Diab Rep. 2019.

. 2019 May 31;19(7):41.

doi: 10.1007/s11892-019-1157-y.

Authors

Drazenka Pongrac Barlovic^{1

2

3

4

5}, Heidi Tikkanen-Dolenc^{3

4

5}, Per-Henrik Groop^{6

7

8

9}

Affiliations

¹ University Medical Center Ljubljana, Ljubljana, Slovenia.
² Faculty of Medicine, University Ljubljana, Ljubljana, Slovenia.
³ Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O Box 63, FIN-00014, Helsinki, Finland.
⁴ Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
⁵ Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
⁶ Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O Box 63, FIN-00014, Helsinki, Finland. per-henrik.groop@helsinki.fi.
⁷ Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. per-henrik.groop@helsinki.fi.
⁸ Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. per-henrik.groop@helsinki.fi.
⁹ Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia. per-henrik.groop@helsinki.fi.

PMID: 31152254
PMCID: PMC6544601
DOI: 10.1007/s11892-019-1157-y

Abstract

Purpose of review: Physical activity is a fundamental part of lifestyle management in diabetes care. Although its benefits are very well recognized in the general population and in people with type 2 diabetes, much less is known about the effects of exercise in type 1 diabetes. In particular, exercise effects in relation to diabetic kidney disease (DKD) are understudied. Some uncertainties about physical activity recommendations stem from the fact that strenuous exercise may worsen albuminuria immediately after the activity. However, in middle-aged and older adults without diabetes, observational studies have suggested that physical activity is associated with a decreased risk of rapid kidney function deterioration. In this review, we focus on the role of physical activity in patients with DKD and type 1 diabetes.

Recent findings: Hereby, we present data that show that in individuals at risk of DKD or with established DKD, regular moderate-to-vigorous physical activity was associated with reduced incidence and progression of DKD, as well as reduced risk of cardiovascular events and mortality. Therefore, regular moderate-to-vigorous exercise should become a central part of the management of individuals with type 1 diabetes, in the absence of contraindications and accompanied with all needed educational support for optimal diabetes management.

Keywords: Chronic kidney disease; Diabetic kidney disease; Exercise; Physical activity; Type 1 diabetes.

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Conflict of interest statement

Drazenka Pongrac Barlovic reports receiving lecture honorariums from Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Krka, Merck, MSD, Novo Nordisk, and Sanofi Aventis; and being an advisory board member of Astra Zeneca, Boehringer Ingelheim, Eli Lilly, and Novo Nordisk.

Per-Henrik Groop reports receiving lecture honorariums from Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Elo Water, Genzyme, Medscape, MSD, Novartis, Novo Nordisk, PeerVoice, and Sanofi; and being an advisory board member of AbbVie, Astellas, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Medscape, MSD, Mundipharma, Novartis, Novo Nordisk, and Sanofi.

Heidi Tikkanen-Dolenc declares that she has no conflict of interest.

Figures

**Fig. 1**
Diagram presenting mechanisms through which exercise influences beneficial outcomes in patients with DKD

See this image and copyright information in PMC

References

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Physical Activity in the Prevention of Development and Progression of Kidney Disease in Type 1 Diabetes

Affiliations

Physical Activity in the Prevention of Development and Progression of Kidney Disease in Type 1 Diabetes

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Research Materials