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Multicenter Study
. 2019 Sep;266(9):2216-2223.
doi: 10.1007/s00415-019-09402-0. Epub 2019 May 31.

Comorbidity and retirement in cervical dystonia

Rebekka M Ortiz  1   2   3 , Filip Scheperjans  4   5 , Tuomas Mertsalmi  4   5 , Eero Pekkonen  4   5
Affiliations
Multicenter Study

Comorbidity and retirement in cervical dystonia

Rebekka M Ortiz et al. J Neurol. 2019 Sep.

Abstract

Background: Cervical dystonia (CD) is the most common form of dystonia. The onset of CD is usually before 60 years of age and it may cause severe functional and psychosocial impairment in everyday life. Recently non-motor symptoms have been reported to occur in CD substantially affecting the quality of life.

Methods/patients: We studied comorbidities of patients with primary focal CD in Finland based on ICD-10 codes obtained from the care registry and patient records of 937 confirmed adult isolated focal CD patients between the years 2007-2016. The retirement months and diagnosis of retirement were calculated from pension registry information. The results were compared with 3746 age and gender-matched controls.

Results: Most prominent comorbidities with primary focal CD were depression (14%), anxiety (7%), and back pain (11%). The retirement age was significantly younger in CD patients compared to control group controls (59.0 years, 95% CI 58.5-59.5 vs. 61.7 years, 95% CI 61.6-61.9) years, p < 0.001). For dystonia patients the most common diagnoses for retirement due to sickness were dystonia (51%), depression (14%), and anxiety (8%). Patients with anxiety and depression retired earlier than other dystonia patients.

Discussion: Cervical dystonia considerably reduces working ability and leads to earlier retirement. Anxiety and depression are most notable comorbidities and their co-occurrence further reduces working ability. Our results suggest that more health care resources should be administered in treatment of CD to longer maintain working ability of CD patients. Further, psychiatric comorbidities should be taken into consideration in CD treatment.

Keywords: Cervical dystonia; Comorbidity; Dystonia; Pension; Working ability.

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Conflict of interest statement

Rebekka Ortiz has received a grant from the Finnish Parkinson Foundation. Filip Scheperjans reports no conflicts of interest relative to the research covered in this study. Tuomas Mertsalmi reports no conflicts of interest relative to the research covered in this study. Eero Pekkonen reports no conflicts of interest relative to the research covered in this study.

Figures

Fig. 1
Fig. 1
Retirement months with patients and controls with and without anxiety or depression. *p < 0.001
Fig. 2
Fig. 2
a The age of retirement between CD patients and controls. b The age of retirement between CD patients and controls when divided into groups weather or not the patients have anxiety or depression. The statistical analysis was done with log-rank test. Anx/dep anxiety or depression. *p < 0.005, **p < 0.001
See this image and copyright information in PMC

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