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Review
. 2019 Jul;35(7):483-486.
doi: 10.1016/j.pt.2019.04.008. Epub 2019 May 29.

Transmission-Blocking Vaccines for Malaria: Time to Talk about Vaccine Introduction

Camila H Coelho  1 , Rino Rappuoli  2 , Peter J Hotez  3 , Patrick E Duffy  4
Affiliations
Review

Transmission-Blocking Vaccines for Malaria: Time to Talk about Vaccine Introduction

Camila H Coelho et al. Trends Parasitol. 2019 Jul.

Abstract

Malaria kills more than 600 000 people yearly, mainly children, and eradication is a global priority. Malaria transmission-blocking vaccines are advancing in clinical trials, and strategies for their introduction must be prioritized among stakeholders and the vulnerable populations exposed to the disease.

Keywords: low-income countries; malaria vaccines; transmission-blocking vaccines; vaccine introduction.

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Figures

Figure 1.
Figure 1.. Mechanism of Action of Transmission-Blocking Vaccines (TBVs) in Malaria-endemic Areas.
TBVs elicit antibodies that are able to neutralize sexual-stage parasites and prevent mosquito infectivity, thereby reducing transmission from one person to the next. TBVs require herd immunity to reduce malaria incidence in the community, including the vaccine recipient. Abbreviation: RBC, red blood cell.
See this image and copyright information in PMC

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