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. 2019 Oct;75(4):486-495.
doi: 10.1111/his.13929. Epub 2019 Aug 19.

Actinomyces in Crohn's-like appendicitis

Bela A Horvath  1 , Elena Maryamchik  2 , Gregory C Miller  3   4 , Ian S Brown  3   4 , Namrata Setia  5 , Anthony R Mattia  6 , Laura Lamps  7 , Gregory Y Lauwers  8 , Eric Rosenberg  2   9 , Joseph Misdraji  2
Affiliations

Actinomyces in Crohn's-like appendicitis

Bela A Horvath et al. Histopathology. 2019 Oct.

Abstract

Aims: Appendicitis with a Crohn's-like histological appearance generally raises concern for Crohn's disease, Yersinia infection, and interval appendectomy. Actinomyces infection is a recognised cause of chronic appendicitis that can histologically mimic Crohn's disease.

Methods and results: We report on 20 cases of appendicitis with Crohn's-like histological features that were due to Actinomyces. Most patients presented with acute or chronic abdominal pain. Imaging studies suggested a mass in five cases. Two patients had interval appendectomy. Histological features showed Crohn's-like appendicitis in 16 cases, with moderate to marked fibrosis and granulomas in seven cases. The other four cases had less consistent histological findings. None of the patients developed Crohn's disease during the follow-up interval (median, 37 months).

Conclusions: Actinomyces can be associated with Crohn's-like appendicitis with marked fibrosis, transmural inflammation, lymphoid hyperplasia, and granulomas.

Keywords: Actinomyces; Crohn’s disease; appendicitis; appendix; granuloma.

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