Editorial: Difficult and Severe Asthma in Children

Andrew Bush^{1

2

3}, Renato Cutrera⁴, Giorgio Piacentini⁵, Francesca Santamaria⁶, Nicola Ullmann⁴

Affiliations

¹ Professor of Paediatrics and Head of Section (Paediatrics), Imperial College London, London, United Kingdom.
² Professor of Paediatric Respirology, National Heart and Lung Institute, London, United Kingdom.
³ Consultant Paediatric Chest Physician, Royal Brompton Harefield NHS Foundation Trust, London, United Kingdom.
⁴ Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy.
⁵ Professor of Paediatrics and Head of Paediatric Section AOUI Verona, University of Verona, Verona, Italy.
⁶ Department of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy.

Editorial

Andrew Bush et al. Front Pediatr. 2019.

. 2019 May 17:7:205.

doi: 10.3389/fped.2019.00205. eCollection 2019.

Andrew Bush^{1

2

3}, Renato Cutrera⁴, Giorgio Piacentini⁵, Francesca Santamaria⁶, Nicola Ullmann⁴

¹ Professor of Paediatrics and Head of Section (Paediatrics), Imperial College London, London, United Kingdom.
² Professor of Paediatric Respirology, National Heart and Lung Institute, London, United Kingdom.
³ Consultant Paediatric Chest Physician, Royal Brompton Harefield NHS Foundation Trust, London, United Kingdom.
⁴ Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy.
⁵ Professor of Paediatrics and Head of Paediatric Section AOUI Verona, University of Verona, Verona, Italy.
⁶ Department of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy.

No abstract available

Keywords: airway inflammation; airway obstruction; allergy; atopy; endotype; eosinphil; phenotype.

Comment on

1. Ebmeier S, Thayabaran D, Braithwaite I, Bénamara C, Weatherall M, Beasley R. Trends in international asthma mortality: analysis of data from the WHO Mortality Database from 46 countries (1993-2012). Lancet. (2017) 390:935–45. 10.1016/S0140-6736(17)31448-4 - DOI - PubMed
1. Bousquet J, Mantzouranis E, Cruz AA, Aït-Khaled N, Baena-Cagnani CE, Bleecker ER, et al. . Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. (2010) 126:926–38. 10.1016/j.jaci.2010.07.019 - DOI - PubMed
1. Bush A. Out of Sight, but should not be out of mind: the hidden lung blood supply. Ann Am Thorac Soc. (2018) 15:1284–5. 10.1513/AnnalsATS.201807-447ED - DOI - PubMed
1. Bush A, Nagakumar P. Preschool wheezing phenotypes. Eur Med J. (2016) 1:93–101. 10.1007/s12098-015-1802-7 - DOI
1. Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, et al. After asthma – redefining airways diseases. A Lancet commission. Lancet. (2018) 391:350–400. 10.1016/S0140-6736(17)30879-6 - DOI - PubMed