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Review
. 2019 Apr;7(7):147.
doi: 10.21037/atm.2019.02.34.

Anti-inflammatory therapy for cardiovascular disease

Constantine E Kosmas  1 , Delia Silverio  2 , Andreas Sourlas  3 , Peter D Montan  2 , Eliscer Guzman  1 , Mario J Garcia  1
Affiliations
Review

Anti-inflammatory therapy for cardiovascular disease

Constantine E Kosmas et al. Ann Transl Med. 2019 Apr.

Abstract

Chronic subclinical inflammation is a central process in the pathogenesis of cardiovascular disease (CVD) and it has been linked with both the initiation and progression of atherosclerosis. Several pro-inflammatory cytokines, such as the C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) have been described as independent risk factors for coronary heart disease and promoters of atherogenesis. Thus, extensive research is being conducted to assess the role of anti-inflammatory therapy in the primary and secondary prevention of CVD. Our review aims to provide the clinical and scientific data pertaining to the effects of different anti-inflammatory agents administered in patients with CVD.

Keywords: Inflammation; anti-inflammatory agents/therapy; cardiovascular disease (CVD); pro-inflammatory cytokines.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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