doi: 10.1093/ajcp/71.2.158.
Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy
- PMID: 311581
- DOI: 10.1093/ajcp/71.2.158
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Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy
Am J Clin Pathol.
1979 Feb.
Abstract
Aberration of IgA-bearing B lymphocytes in patients with IgA nephropathy has been investigated. Twelve patients with IgA nephropathy demonstrated a marked increase of IgA-bearing lymphocytes in peripheral blood, while ten patients with chronic proliferative glomerulonephritis without mesangial deposition of IgA showed normal amounts of IgA-bearing lymphocytes. The increase of IgA-bearing lymphocytes reflected that of IgA-producing lymphocytes, since lymphocytes obtained from patients with IgA nephropathy restored a high percentage of IgA-bearing cells in vitro after treatment with trypsin. Quantitation of IgA-bearing lymphocytes in peripheral blood is a useful method for screening of patients with IgA nephropathy.
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