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. 1979 Feb;71(2):158-60.
doi: 10.1093/ajcp/71.2.158.

Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy

Y Nomoto, H Sakai, S Arimori

Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy

Y Nomoto et al. Am J Clin Pathol. 1979 Feb.

Abstract

Aberration of IgA-bearing B lymphocytes in patients with IgA nephropathy has been investigated. Twelve patients with IgA nephropathy demonstrated a marked increase of IgA-bearing lymphocytes in peripheral blood, while ten patients with chronic proliferative glomerulonephritis without mesangial deposition of IgA showed normal amounts of IgA-bearing lymphocytes. The increase of IgA-bearing lymphocytes reflected that of IgA-producing lymphocytes, since lymphocytes obtained from patients with IgA nephropathy restored a high percentage of IgA-bearing cells in vitro after treatment with trypsin. Quantitation of IgA-bearing lymphocytes in peripheral blood is a useful method for screening of patients with IgA nephropathy.

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