Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug:61:89-94.
doi: 10.1016/j.canep.2019.05.007. Epub 2019 May 31.

Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

Haitham Mirghani  1 , Carine Bellera  2 , Jessy Delaye  3 , Gilles Dolivet  4 , Nicolas Fakhry  5 , Alexandre Bozec  6 , Renaud Garrel  7 , Olivier Malard  8 , Franck Jegoux  9 , Philippe Maingon  10 , Jérome Sarini  11 , Georges Noel  12 , Suzy Duflo  13 , Stéphane Temam  14 , Jean-Louis Lefebvre  15 , Valérie Costes-Martineau  16
Affiliations

Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

Haitham Mirghani et al. Cancer Epidemiol. 2019 Aug.

Abstract

Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV) remains poorly investigated.

Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both p16-immunohistochemistry and HPV-DNA assays were positive. Demographical and clinical features were recorded.

Results: 291 patients with palatine-tonsil or tongue-base cancers were recruited from March-2011 to July-2012. Of these, 43.1% of samples were p16-positive and 37.7% were positive for both p16 and HPV-DNA. Prognosis was significantly better in patients with HPV-driven cancers, with smoking negatively impacting patients' oncological outcomes.

Conclusion: In France, more than a third of tonsillar and tongue base cancers are HPV-driven. More research concerning the evolution of HPV-driven cancers over time is needed.

Keywords: France; Human papillomavirus (HPV); cancer(s); epidemiology; neoplasm(s); oral/oropharynx/oropharyngeal; prevalence; tonsil/tonsillar.

PubMed Disclaimer

LinkOut - more resources