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Review
. 2019 Jun;15(18):2151-2162.
doi: 10.2217/fon-2018-0915. Epub 2019 Jun 4.

BAP1 in solid tumors

Vincenzo Di Nunno  1 , Giorgio Frega  2 , Matteo Santoni  3 , Lidia Gatto  2 , Michelangelo Fiorentino  4 , Rodolfo Montironi  5 , Nicola Battelli  3 , Giovanni Brandi  2 , Francesco Massari  1
Affiliations
Review

BAP1 in solid tumors

Vincenzo Di Nunno et al. Future Oncol. 2019 Jun.

Abstract

One of the most attractive cancer-related genes under investigation is BAP1. Reasons of this growing interest are related to the wide spectrum of pathways directly or indirectly modulated by this gene and shared by several solid tumors. Programmed cell-death, cell metabolisms, immune cells development, ferroptosis and defects in DNA damage response are only some of the multitude of processes depending on BAP1. Loss of this gene seems to occur in different times of tumor history. Moreover, times of BAP1 loss strongly diverge among primary tumors suggesting the presence of several and different triggering factors. Regardless of when it happens, BAP1 loss usually results in prognosis worsening and in the acquisition of more aggressive clinical features by cancer cells.

Keywords: BAP1; cholangiocarcinoma; melanoma; mesothelioma; renal cell carcinoma; thymic carcinoma.

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