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. 2019 Jun 3;19(1):55.
doi: 10.1186/s12902-019-0386-z.

Total adiponectin in overweight and obese subjects and its response to visceral fat loss

Salah Gariballa  1 , Juma Alkaabi  2 , Javed Yasin  2 , Awad Al Essa  2
Affiliations

Total adiponectin in overweight and obese subjects and its response to visceral fat loss

Salah Gariballa et al. BMC Endocr Disord. .

Abstract

Background: Visceral obesity and related diabetes is reaching epidemic proportions in the United Arab Emirates (UAE). Adiponectin is a hormone that is secreted by adipose tissue and may play an important role in obesity-related morbidity. The aim of this study was to investigate total adiponectin levels in overweight and obese UAE subjects visiting health care facilities for weight management.

Methods: All overweight and obese subjects visiting community health centers were invited to take part in the study. Two hundred and six participants received individualized structured dietary education for weight management. Demographic data, anthropometric measurements and fasting venous blood samples were taken for measurements of total adiponectin and markers of inflammation and nutritional status at baseline and follow up. Multivariate analysis was performed to determine the independent effects of prognostic factors on serum adiponectin levels.

Results: A total of 193 (93%) females with a mean age (±SD) 36 ± 11 years were included in the analysis. During a follow up period of 427 ± 223 days, participants received 13 ± 5 structured dietary education sessions. We observed decreased levels of total adiponectin with increasing quartiles of both waist circumference (WC) and body mass index (BMI). Male gender and history of both gestational and type 2 diabetes were associated with significantly lower total adiponectin levels (p < 0.05). After adjusting for age, gender, BMI and hip circumference, multiple regression analysis revealed a significant and independent association between waist circumference and total adiponectin levels. At follow up visceral fat loss was associated with a significant decrease in inflammatory markers and a non-significant increase in total adiponectin levels.

Conclusion: Increased visceral fat in overweight and obese subjects is associated with decreased total adiponectin levels. The health benefits of increasing adiponectin levels using different dietary intervention strategies need to be explored in larger studies.

Trial registration: NCT01691365 , registered on 11/09/2012.

Keywords: Adiponectin; Diet; Obesity; Visceral fat.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Baseline adiponectin levels (μg/ml), [mean (SD)], according to quartiles of waist circumference (WC) of female subjects
Fig. 2
Fig. 2
Baseline adiponectin levels (μg/ml), [mean (SD)], according to quartiles of body mass index (BMI) mean (SD) of female subjects
Fig. 3
Fig. 3
Association between total adiponectin and high density lipoproteins in overweight and obese subjects
See this image and copyright information in PMC

References

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