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Comment
. 2019 Aug;44(8):645-647.
doi: 10.1016/j.tibs.2019.04.013. Epub 2019 May 31.

DNA Content, Cell Size, and Cell Senescence

Reiner A Veitia  1
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DNA Content, Cell Size, and Cell Senescence

Reiner A Veitia. Trends Biochem Sci. 2019 Aug.

Abstract

A recent study assessed the impact of cell size on various cell properties. Oversized yeast cells display slow cell division, cytoplasmic dilution, and transcriptomic and proteomic alterations. It highlights commonalities between aging yeast and mammalian cells, suggesting the existence of a range of DNA content: cell volume ratio ensuring optimal function.

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  • Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence.
    Neurohr GE, Terry RL, Lengefeld J, Bonney M, Brittingham GP, Moretto F, Miettinen TP, Vaites LP, Soares LM, Paulo JA, Harper JW, Buratowski S, Manalis S, van Werven FJ, Holt LJ, Amon A. Neurohr GE, et al. Cell. 2019 Feb 21;176(5):1083-1097.e18. doi: 10.1016/j.cell.2019.01.018. Epub 2019 Feb 7. Cell. 2019. PMID: 30739799 Free PMC article.

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