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Comment
. 2019 Jun;9(6):696-698.
doi: 10.1158/2159-8290.CD-19-0406.

RAS Mutations Are Not Created Equal

G Aaron Hobbs  1 , Channing J Der  2   3
Affiliations
Comment

RAS Mutations Are Not Created Equal

G Aaron Hobbs et al. Cancer Discov. 2019 Jun.

Abstract

In this issue of Cancer Discovery, Poulin and colleagues apply structural, biochemical, and biological profiling of two mutants of KRAS, one found most frequently in all cancers (G12D) and one found nearly exclusively in colorectal cancer (A146T). They provide compelling evidence that specific mutations will impart different structural and biochemical consequences on KRAS function and that the same KRAS mutation displays tissue-distinct signaling and biological consequences.See related article by Poulin et al., p. 738.

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  • Tissue-Specific Oncogenic Activity of KRASA146T.
    Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. Poulin EJ, et al. Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5. Cancer Discov. 2019. PMID: 30952657 Free PMC article.

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