Published Erratum
doi: 10.1038/s41588-019-0450-7.
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Antonio F Pardiñas
1
, Peter Holmans
1
, Andrew J Pocklington
1
, Valentina Escott-Price
1
, Stephan Ripke
2
3
, Noa Carrera
1
, Sophie E Legge
1
, Sophie Bishop
1
, Darren Cameron
1
, Marian L Hamshere
1
, Jun Han
1
, Leon Hubbard
1
, Amy Lynham
1
, Kiran Mantripragada
1
, Elliott Rees
1
, James H MacCabe
4
, Steven A McCarroll
5
, Bernhard T Baune
6
, Gerome Breen
7
8
, Enda M Byrne
9
10
, Udo Dannlowski
11
, Thalia C Eley
7
, Caroline Hayward
12
, Nicholas G Martin
13
14
, Andrew M McIntosh
15
16
, Robert Plomin
7
, David J Porteous
12
, Naomi R Wray
9
10
, Armando Caballero
17
, Daniel H Geschwind
18
, Laura M Huckins
19
, Douglas M Ruderfer
19
, Enrique Santiago
20
, Pamela Sklar
19
, Eli A Stahl
19
, Hyejung Won
18
, Esben Agerbo
21
22
, Thomas D Als
21
23
24
, Ole A Andreassen
25
26
, Marie Bækvad-Hansen
21
27
, Preben Bo Mortensen
21
22
23
, Carsten Bøcker Pedersen
21
22
, Anders D Børglum
21
23
24
, Jonas Bybjerg-Grauholm
21
27
, Srdjan Djurovic
28
29
, Naser Durmishi
30
, Marianne Giørtz Pedersen
21
22
, Vera Golimbet
31
, Jakob Grove
21
23
24
32
, David M Hougaard
21
27
, Manuel Mattheisen
21
23
24
, Espen Molden
33
, Ole Mors
21
34
, Merete Nordentoft
21
35
, Milica Pejovic-Milovancevic
36
, Engilbert Sigurdsson
37
, Teimuraz Silagadze
38
, Christine Søholm Hansen
21
27
, Kari Stefansson
39
, Hreinn Stefansson
39
, Stacy Steinberg
39
, Sarah Tosato
40
, Thomas Werge
21
41
42
; GERAD1 Consortium; CRESTAR Consortium; David A Collier
7
43
, Dan Rujescu
44
45
, George Kirov
1
, Michael J Owen
46
, Michael C O'Donovan
47
, James T R Walters
48
Collaborators,
Affiliations
Collaborators
-
Denise Harold, Rebecca Sims, Amy Gerrish, Jade Chapman, Valentina Escott-Price, Richard Abraham, Paul Hollingworth, Jaspreet Pahwa, Nicola Denning, Charlene Thomas, Sarah Taylor, John Powell, Petroula Proitsi, Michelle Lupton, Simon Lovestone, Peter Passmore, David Craig, Bernadette McGuinness, Janet Johnston, Stephen Todd, Wolfgang Maier, Frank Jessen, Reiner Heun, Britta Schurmann, Alfredo Ramirez, Tim Becker, Christine Herold, André Lacour, Dmitriy Drichel, Markus Nothen, Alison Goate, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Peter Holmans, Michael O'Donovan, Michael Owen, Julie Williams, Evanthia Achilla, Esben Agerbo, Cathy L Barr, Theresa Wimberly Böttger, Gerome Breen, Dan Cohen, David A Collier, Sarah Curran, Emma Dempster, Danai Dima, Ramon Sabes-Figuera, Robert J Flanagan, Sophia Frangou, Josef Frank, Christiane Gasse, Fiona Gaughran, Ina Giegling, Jakob Grove, Eilis Hannon, Annette M Hartmann, Barbara Heißerer, Marinka Helthuis, Henriette Thisted Horsdal, Oddur Ingimarsson, Karel Jollie, James L Kennedy, Ole Köhler, Bettina Konte, Maren Lang, Sophie E Legge, Cathryn Lewis, James MacCabe, Anil K Malhotra, Paul McCrone, Sandra M Meier, Jonathan Mill, Ole Mors, Preben Bo Mortensen, Markus M Nöthen, Michael C O'Donovan, Michael J Owen, Antonio F Pardiñas, Carsten B Pedersen, Marcella Rietschel, Dan Rujescu, Ameli Schwalber, Engilbert Sigurdsson, Holger J Sørensen, Benjamin Spencer, Hreinn Stefansson, Henrik Støvring, Jana Strohmaier, Patrick Sullivan, Evangelos Vassos, Moira Verbelen, James T R Walters, Thomas Werge
Affiliations
- 1 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
- 2 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
- 3 Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany.
- 4 Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 5 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 6 Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
- 7 MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 8 NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 9 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
- 10 Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
- 11 Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
- 12 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 13 School of Psychology, University of Queensland, Brisbane, Queensland, Australia.
- 14 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 15 Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
- 16 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
- 17 Departamento de Bioquímica, Genética e Inmunología. Facultad de Biología, Universidad de Vigo, Vigo, Spain.
- 18 Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
- 19 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 20 Departamento de Biología Funcional. Facultad de Biología, Universidad de Oviedo, Oviedo, Spain.
- 21 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
- 22 National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
- 23 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
- 24 Department of Biomedicine- Human Genetics, Aarhus University, Aarhus, Denmark.
- 25 Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 26 NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
- 27 Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
- 28 NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 29 Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
- 30 Department of Child and Adolescent Psychiatry, University Clinic of Psychiatry, Skopje, Macedonia.
- 31 Department of Clinical Genetics, Mental Health Research Center, Moscow, Russia.
- 32 Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
- 33 Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
- 34 Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
- 35 Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
- 36 Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia.
- 37 Department of Psychiatry, National University Hospital, Reykjavik, Iceland.
- 38 Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.
- 39 deCODE Genetics, Reykjavik, Iceland.
- 40 Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Verona, Italy.
- 41 Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
- 42 Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
- 43 Discovery Neuroscience Research, Eli Lilly and Company, Lilly Research Laboratories, Windlesham, UK.
- 44 Department of Psychiatry, University of Halle, Halle, Germany.
- 45 Department of Psychiatry, University of Munich, Munich, Germany.
- 46 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. owenmj@cardiff.ac.uk.
- 47 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. odonovanmc@cardiff.ac.uk.
- 48 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. waltersjt@cardiff.ac.uk.
- PMID: 31160808
- DOI: 10.1038/s41588-019-0450-7
Item in Clipboard
Published Erratum
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Antonio F Pardiñas et al.
Nat Genet.
2019 Jul.
Free article
Display options
Format
doi: 10.1038/s41588-019-0450-7.
Authors
Antonio F Pardiñas
1
, Peter Holmans
1
, Andrew J Pocklington
1
, Valentina Escott-Price
1
, Stephan Ripke
2
3
, Noa Carrera
1
, Sophie E Legge
1
, Sophie Bishop
1
, Darren Cameron
1
, Marian L Hamshere
1
, Jun Han
1
, Leon Hubbard
1
, Amy Lynham
1
, Kiran Mantripragada
1
, Elliott Rees
1
, James H MacCabe
4
, Steven A McCarroll
5
, Bernhard T Baune
6
, Gerome Breen
7
8
, Enda M Byrne
9
10
, Udo Dannlowski
11
, Thalia C Eley
7
, Caroline Hayward
12
, Nicholas G Martin
13
14
, Andrew M McIntosh
15
16
, Robert Plomin
7
, David J Porteous
12
, Naomi R Wray
9
10
, Armando Caballero
17
, Daniel H Geschwind
18
, Laura M Huckins
19
, Douglas M Ruderfer
19
, Enrique Santiago
20
, Pamela Sklar
19
, Eli A Stahl
19
, Hyejung Won
18
, Esben Agerbo
21
22
, Thomas D Als
21
23
24
, Ole A Andreassen
25
26
, Marie Bækvad-Hansen
21
27
, Preben Bo Mortensen
21
22
23
, Carsten Bøcker Pedersen
21
22
, Anders D Børglum
21
23
24
, Jonas Bybjerg-Grauholm
21
27
, Srdjan Djurovic
28
29
, Naser Durmishi
30
, Marianne Giørtz Pedersen
21
22
, Vera Golimbet
31
, Jakob Grove
21
23
24
32
, David M Hougaard
21
27
, Manuel Mattheisen
21
23
24
, Espen Molden
33
, Ole Mors
21
34
, Merete Nordentoft
21
35
, Milica Pejovic-Milovancevic
36
, Engilbert Sigurdsson
37
, Teimuraz Silagadze
38
, Christine Søholm Hansen
21
27
, Kari Stefansson
39
, Hreinn Stefansson
39
, Stacy Steinberg
39
, Sarah Tosato
40
, Thomas Werge
21
41
42
; GERAD1 Consortium; CRESTAR Consortium; David A Collier
7
43
, Dan Rujescu
44
45
, George Kirov
1
, Michael J Owen
46
, Michael C O'Donovan
47
, James T R Walters
48
Collaborators
-
Denise Harold, Rebecca Sims, Amy Gerrish, Jade Chapman, Valentina Escott-Price, Richard Abraham, Paul Hollingworth, Jaspreet Pahwa, Nicola Denning, Charlene Thomas, Sarah Taylor, John Powell, Petroula Proitsi, Michelle Lupton, Simon Lovestone, Peter Passmore, David Craig, Bernadette McGuinness, Janet Johnston, Stephen Todd, Wolfgang Maier, Frank Jessen, Reiner Heun, Britta Schurmann, Alfredo Ramirez, Tim Becker, Christine Herold, André Lacour, Dmitriy Drichel, Markus Nothen, Alison Goate, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Peter Holmans, Michael O'Donovan, Michael Owen, Julie Williams, Evanthia Achilla, Esben Agerbo, Cathy L Barr, Theresa Wimberly Böttger, Gerome Breen, Dan Cohen, David A Collier, Sarah Curran, Emma Dempster, Danai Dima, Ramon Sabes-Figuera, Robert J Flanagan, Sophia Frangou, Josef Frank, Christiane Gasse, Fiona Gaughran, Ina Giegling, Jakob Grove, Eilis Hannon, Annette M Hartmann, Barbara Heißerer, Marinka Helthuis, Henriette Thisted Horsdal, Oddur Ingimarsson, Karel Jollie, James L Kennedy, Ole Köhler, Bettina Konte, Maren Lang, Sophie E Legge, Cathryn Lewis, James MacCabe, Anil K Malhotra, Paul McCrone, Sandra M Meier, Jonathan Mill, Ole Mors, Preben Bo Mortensen, Markus M Nöthen, Michael C O'Donovan, Michael J Owen, Antonio F Pardiñas, Carsten B Pedersen, Marcella Rietschel, Dan Rujescu, Ameli Schwalber, Engilbert Sigurdsson, Holger J Sørensen, Benjamin Spencer, Hreinn Stefansson, Henrik Støvring, Jana Strohmaier, Patrick Sullivan, Evangelos Vassos, Moira Verbelen, James T R Walters, Thomas Werge
Affiliations
- 1 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
- 2 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
- 3 Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany.
- 4 Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 5 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 6 Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
- 7 MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 8 NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 9 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
- 10 Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
- 11 Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
- 12 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 13 School of Psychology, University of Queensland, Brisbane, Queensland, Australia.
- 14 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 15 Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
- 16 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
- 17 Departamento de Bioquímica, Genética e Inmunología. Facultad de Biología, Universidad de Vigo, Vigo, Spain.
- 18 Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
- 19 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 20 Departamento de Biología Funcional. Facultad de Biología, Universidad de Oviedo, Oviedo, Spain.
- 21 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
- 22 National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
- 23 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
- 24 Department of Biomedicine- Human Genetics, Aarhus University, Aarhus, Denmark.
- 25 Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 26 NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
- 27 Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
- 28 NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 29 Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
- 30 Department of Child and Adolescent Psychiatry, University Clinic of Psychiatry, Skopje, Macedonia.
- 31 Department of Clinical Genetics, Mental Health Research Center, Moscow, Russia.
- 32 Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
- 33 Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
- 34 Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
- 35 Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
- 36 Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia.
- 37 Department of Psychiatry, National University Hospital, Reykjavik, Iceland.
- 38 Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.
- 39 deCODE Genetics, Reykjavik, Iceland.
- 40 Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Verona, Italy.
- 41 Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
- 42 Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
- 43 Discovery Neuroscience Research, Eli Lilly and Company, Lilly Research Laboratories, Windlesham, UK.
- 44 Department of Psychiatry, University of Halle, Halle, Germany.
- 45 Department of Psychiatry, University of Munich, Munich, Germany.
- 46 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. owenmj@cardiff.ac.uk.
- 47 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. odonovanmc@cardiff.ac.uk.
- 48 MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. waltersjt@cardiff.ac.uk.
- PMID: 31160808
- DOI: 10.1038/s41588-019-0450-7
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Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Erratum for
-
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB, Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T; GERAD1 Consortium; CRESTAR Consortium; Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR. Pardiñas AF, et al. Nat Genet. 2018 Mar;50(3):381-389. doi: 10.1038/s41588-018-0059-2. Epub 2018 Feb 26. Nat Genet. 2018. PMID: 29483656 Free PMC article.
