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. 1979 Jan;15(1):123-5.
doi: 10.1128/AAC.15.1.123.

Production of beta-lactamase by non-streptomyces Actinomycetales

J L Schwartz, S P Schwartz

Production of beta-lactamase by non-streptomyces Actinomycetales

J L Schwartz et al. Antimicrob Agents Chemother. 1979 Jan.

Abstract

Supernatants and whole cells from fermentation broths of Micromonospora, Nocardia, Oerskovia, and other genera of the Actinomycetales were examined for the presence of beta-lactamase activity by using the chromogenic cephalosporin 87/312. Nearly 60% of the 250 isolates examined produced detectable levels of beta-lactamase. All enzyme preparations were active over a range of pH values from 6.5 to 8.2, with maximum activity occurring between 7.0 and 7.8. The preparations varied in their stability at 60 degrees C. An examination of selected enzyme preparations revealed a similarity between substrate specificities of the non-Streptomyces Actinomycetales and gram-negative-bacterial beta-lactamases.

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References

    1. Antimicrob Agents Chemother. 1978 Mar;13(3):373-82 - PubMed
    1. Antimicrob Agents Chemother. 1978 May;13(5):865-70 - PubMed
    1. Antimicrob Agents Chemother. 1976 Jul;10(1):106-11 - PubMed
    1. Antimicrob Agents Chemother. 1972 Apr;1(4):283-8 - PubMed
    1. Antimicrob Agents Chemother. 1975 Oct;8(4):402-8 - PubMed

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