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. 2019 Jul 15;200(2):258-261.
doi: 10.1164/rccm.201903-0503LE.

Type I Collagen-targeted Positron Emission Tomography Imaging in Idiopathic Pulmonary Fibrosis: First-in-Human Studies

Sydney B Montesi  1   2 , David Izquierdo-Garcia  1   2 , Pauline Désogère  1 , Eric Abston  1 , Lloyd L Liang  1 , Subba Digumarthy  1   2 , Ravi Seethamraju  3 , Michael Lanuti  1   2 , Peter Caravan  1   2 , Ciprian Catana  1   2
Affiliations

Type I Collagen-targeted Positron Emission Tomography Imaging in Idiopathic Pulmonary Fibrosis: First-in-Human Studies

Sydney B Montesi et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
68Ga-CBP8 standardized uptake values (SUVs). Data are reported as box-and-whisker plots. *P < 0.05 and **P < 0.01 for subjects with idiopathic pulmonary fibrosis (IPF) compared with healthy volunteers.
Figure 2.
Figure 2.
Collagen-targeted molecular imaging using 68Ga-CBP8 positron emission tomography (PET). (A) Coronal PET image of a healthy volunteer, demonstrating low collagen tracer signal in the lungs. (B) PET image of a subject with idiopathic pulmonary fibrosis rendered on the same scale as in A, demonstrating areas of high collagen tracer signal predominantly in subpleural and basilar regions in the lungs. (C) High-resolution computed tomography (CT) of the same subject with idiopathic pulmonary fibrosis obtained within 8 weeks of PET–magnetic resonance imaging. Compared with the PET imaging (B), increased collagen tracer signal is not confined to areas of fibrosis visualized on CT. White arrows highlight regions of high tracer signal within areas of lung without apparent fibrosis on CT. Red arrows highlight regions of high tracer signal within areas of established fibrosis on CT.
See this image and copyright information in PMC

References

    1. Désogère P, Tapias LF, Hariri LP, Rotile NJ, Rietz TA, Probst CK, et al. Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models. Sci Transl Med. 2017;9:eaaf4696. - PMC - PubMed
    1. Montesi SB, Izquierdo-Garcia D, Abston E, Désogère P, Digumarthy SR, Seethamraju R, et al. Collagen-targeted PET imaging in idiopathic pulmonary fibrosis: first-in-human studies [abstract] Am J Respir Crit Care Med. 2019;199:A7349. - PMC - PubMed
    1. Montesi SB, Rao R, Liang LL, Goulart HE, Sharma A, Digumarthy SR, et al. Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis. Eur Respir J. 2018;51:1800171. - PMC - PubMed
    1. Montesi SB, Désogère P, Fuchs BC, Caravan P. Molecular imaging of fibrosis: recent advances and future directions. J Clin Invest. 2019;129:24–33. - PMC - PubMed
    1. Désogère P, Montesi SB, Caravan P. Molecular probes for imaging fibrosis and fibrogenesis. Chemistry. 2019;25:1128–1141. - PMC - PubMed

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