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Comment
. 2019 Dec;13(1):168-171.
doi: 10.1080/19336950.2019.1618149.

Mechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels

Oleg Yarishkin  1 , Jackson M Baumann  1   2 , David Križaj  1   2   3
Affiliations
Comment

Mechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels

Oleg Yarishkin et al. Channels (Austin). 2019 Dec.
No abstract available

Keywords: Mechanotransduction; TREK-1; TRPV4; Trabecular meshwork.

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Figures

Figure 1.
Figure 1.
Arachidonic acid induces transient depolarization followed by sustained hyperpolarization of the plasma membrane.
Figure 2.
Figure 2.
Schematic diagram illustrating a regulatory role of TREK-1 in the TM contractility. The mechanical stress-induced the plasma membrane depolarizing influx of Na+ and Ca2+ through TRPV4 channels. This TRPV4-mediated hyperpolarization might facilitate Ca2+ influx via voltage-gated calcium channels (VOCC) thus increasing the contractility of TM. Besides that, TRPV4-induced elevation of intracellular Ca2+ results in augmentation of the TM cells stiffness by strengthening of F-actin stress fibers. Synergistically activated potassium channel TREK-1 facilitates the TM cells relaxation acting as a hyperpolarizing factor that opposes excessive depolarization and limits the activation of VOCC. The activity of both TREK-1 and TRPV4 can be regulated via PLA2 pathways, which involves direct modulation by arachidonic acid and its metabolites.
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