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Comment
. 2019 Jun 18;116(25):12136-12138.
doi: 10.1073/pnas.1907647116. Epub 2019 Jun 4.

How Chlamydia trachomatis conquered gut microbiome-derived antimicrobial compounds and found a new home in the eye

Arkaprabha Banerjee  1 , David E Nelson  2
Affiliations
Comment

How Chlamydia trachomatis conquered gut microbiome-derived antimicrobial compounds and found a new home in the eye

Arkaprabha Banerjee et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
De-repression of trpBA operon by indole derivatives in tryptophan-replete conditions. (A) Transcription of trpBA is blocked by TrpR bound to tryptophan corepressor. (B) In tryptophan-deficient conditions, indole is salvaged by tryptophan synthase holoenzyme to produce tryptophan. (C) Indole metabolites (IPA, IAA) replace tryptophan bound to TrpR, causing operon de-repression of trpBA expression in the absence of indole, leading to generation of ammonia from serine by an alternate β-elimination reaction. P, promoter.
See this image and copyright information in PMC

Comment on

References

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