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. 2018 Mar 22;1(2):11.
doi: 10.3390/mps1020011.

Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India

Manoja Kumar Das  1 , Narendra Kumar Arora  2 , Jan Bonhoeffer  3   4 , Patrick L F Zuber  5 , Christine G Maure  6
Affiliations

Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India

Manoja Kumar Das et al. Methods Protoc. .

Abstract

India has recently introduced a rotavirus vaccine under a universal immunization program. There is limited information on intussusception, an adverse event, following immunization in children from India. We are conducting sentinel surveillance for intussusception in children aged under two years at 19 hospitals. The sentinel sites' selection followed a multistage process. The surveillance combines retrospective surveillance for 69 months and prospective surveillance for 18 months. The suspected intussusception cases shall be reviewed for capturing confirmed cases and detailed data collection and classification according to Brighton Collaboration criteria. Data shall be analysed to describe epidemiology, trends, regional and seasonal variations, clinical profiles, management modalities, and outcomes of intussusception. The combination of prospective and retrospective surveillance shall be informative about the trend of intussusception over the last seven years in India. At four sites where rotavirus vaccines have been introduced, the change in intussusception trends shall be documented. The potential association with rotavirus vaccines and other vaccines shall be assessed using case-control and self-controlled case series methodology. Results are forthcoming. The results shall support the national vaccine safety surveillance effort by providing baseline estimates of intussusception for continued monitoring. The surveillance protocol and site selection processes shall inform similar vaccine-safety surveillance in India and other developing countries.

Keywords: intussusception; prospective; retrospective; rotavirus vaccine; surveillance.

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Conflict of interest statement

The authors declare no conflict of interest. The findings and conclusions in this report are those of the authors and do not necessarily represent the official positions of the World Health Organization.

Figures

Figure 1
Figure 1
Surveillance network sites and rotavirus vaccine introduction in India.
See this image and copyright information in PMC

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