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Review
. 2019 May 30:24:36.
doi: 10.1186/s11658-019-0158-9. eCollection 2019.

The role of different SIRT1-mediated signaling pathways in toxic injury

Zhihua Ren #  1 , Hongyi He #  1 , Zhicai Zuo #  1 , Zhiwen Xu  1 , Zhanyong Wei  2 , Junliang Deng  1
Affiliations
Review

The role of different SIRT1-mediated signaling pathways in toxic injury

Zhihua Ren et al. Cell Mol Biol Lett. .

Abstract

Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation, induction of apoptosis, and inhibition of energy metabolism. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase, is a member of the evolutionarily highly conserved Sir2 (silent information regulator 2) superprotein family, which is located in the nucleus and cytoplasm. It can deacetylate protein substrates in various signal transduction pathways to regulate gene expression, cell apoptosis and senescence, participate in the process of neuroprotection, energy metabolism, inflammation and the oxidative stress response in living organisms, and plays an important role in toxic damage caused by toxicants and in the process of SIRT1 activator/inhibitor antagonized toxic damage. This review summarizes the role that SIRT1 plays in toxic damage caused by toxicants via its interactions with protein substrates in certain signaling pathways.

Keywords: SIRT1; SIRT1 activator; Signaling pathway; Toxicant.

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Conflict of interest statement

Competing interestsThis article has not been published elsewhere in whole or in part. All authors have read and approved the content, and agree to submit for consideration for publication in the journal. The authors declared no conflict of interest. All work complies with the Ethical Policies of Cellular & Molecular Biology Letters and has been conducted under internationally accepted ethical standards after relevant ethical review.

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The role of different SIRT1-mediated signaling pathways
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