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Review
. 2019 Nov 25;58(48):17118-17129.
doi: 10.1002/anie.201904795. Epub 2019 Sep 18.

The Buchwald-Hartwig Amination After 25 Years

Ruth Dorel  1 , Christian P Grugel  2 , Alexander M Haydl  3
Affiliations
Review

The Buchwald-Hartwig Amination After 25 Years

Ruth Dorel et al. Angew Chem Int Ed Engl. .

Abstract

The Pd-catalyzed coupling of aryl (pseudo)halides and amines is one of the most powerful approaches for the formation of C(sp2 )-N bonds. The pioneering reports from Migita and subsequently Buchwald and Hartwig on the coupling of aminostannanes and aryl bromides rapidly evolved into general and practical tin-free protocols with broad substrate scope, which led to the establishment of what is now known as the Buchwald-Hartwig amination. This Minireview summarizes the evolution of this cross-coupling reaction over the course of the past 25 years and illustrates some of the most recent applications of this well-established methodology.

Keywords: amination; arenes; cross-coupling; palladium; reaction mechanisms.

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References

    1. For selected reviews, see:
    1. J. F. Hartwig, Angew. Chem. Int. Ed. 1998, 37, 2046-2067;
    1. Angew. Chem. 1998, 110, 2154-2177;
    1. B. H. Yang, S. L. Buchwald, J. Organomet. Chem. 1999, 576, 125-146;
    1. R. J. Lundgren, M. Stradiotto, Chem. Eur. J. 2012, 18, 9758-9769;

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