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. 2018;107(25):1409-1412.
doi: 10.1024/1661-8157/a003144.

[Rare Complication of a Common Disease: Thyroid and Epileptic Seizures]

[Article in German]
Affiliations

[Rare Complication of a Common Disease: Thyroid and Epileptic Seizures]

[Article in German]
Cordula Cadus et al. Praxis (Bern 1994). 2018.

Abstract

Rare Complication of a Common Disease: Thyroid and Epileptic Seizures Abstract. A myxedema crisis is a life-threatening complication of hypothyroidism (mortality 20-25 %). The diagnosis is made on clinical grounds and thyroid function tests. Treatment with levothyroxine (possibly combined with T3) should be instituted immediately, along with glucocorticoids, until co-existing adrenal insufficiency has been ruled out. Supportive measures and treatment of underlying diseases should be implemented. We are presenting the case of a patient with myxedema crisis complicated by tonic-clonic seizures and severe hyponatremia as first manifestation of primary hypothyroidism.

Zusammenfassung. Die Myxödemkrise ist eine lebensbedrohliche Komplikation einer nicht oder unzureichend behandelten Hypothyreose (Mortalität 20–25 %). Die Diagnosestellung erfolgt anhand der klassischen klinischen Präsentation verbunden mit dem laborchemischen Nachweis einer Hypothyreose. Neben supportiven Massnahmen und der Behandlung auslösender Faktoren soll die Therapie mit Levothyroxin (ggf. zusätzlich T3) aufgrund der hohen Mortalität rasch erfolgen, bis zum Ausschluss einer Nebennierenrindeninsuffizienz mit begleitender Glukokortikoidsubstitution. Wir präsentieren den Fall einer Patientin mit Myxödemkrise bei Erstdiagnose einer Hypothyreose mit epileptischen Anfällen und schwerer Hyponatriämie.

Keywords: Hyponatriämie; Hypothyreose; Myxedema crisis; Myxödemkrise; epileptic seizures; epileptische Anfälle; hyponatriemia; hypothyreosis.

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