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Comment
. 2019 Jun 4;29(6):1236-1238.
doi: 10.1016/j.cmet.2019.05.013.

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Curtis C Hughey  1 , Peter A Crawford  2
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Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Curtis C Hughey et al. Cell Metab. .
Free article

Abstract

Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

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