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Comment
. 2019 Jun 4;29(6):1238-1240.
doi: 10.1016/j.cmet.2019.05.011.

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Antonio Sica  1 , Augusto Bleve  2 , Marina Chiara Garassino  3
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Comment

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Antonio Sica et al. Cell Metab. .
Free article

Abstract

The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

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