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. 2018 Sep;57(3):458-463.
doi: 10.20471/acc.2018.57.03.08.

PRO-OXIDANTS AND ANTIOXIDANTS IN RETINOPATHY OF PREMATURITY

Lidija Banjac  1 , Goran Banjac  1 , Jelena Kotur-Stevuljević  1 , Vesna Spasojević-Kalimanovska  1 , Tamara Gojković  1 , Nataša Bogavac-Stanojević  1 , Zorana Jelić-Ivanović  1 , Gorica Banjac  1
Affiliations

PRO-OXIDANTS AND ANTIOXIDANTS IN RETINOPATHY OF PREMATURITY

Lidija Banjac et al. Acta Clin Croat. 2018 Sep.

Abstract

- Premature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful effects by antioxidants. The proliferative phase 2 ROP occurs at around 33rd postmenstrual week (pmw). The purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33rd pmw. The study included 59 premature infants. ROP was classified according to the International Classification of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. The values of the pro-oxidants TOS and MDA were significantly higher in infants with ROP as compared to infants without ROP (p<0.05 both). There were no significant differences in the values of TAS and PON1 between the infants with and without ROP. According to study results, TOS and MDA are good markers of oxidative stress, whereas TAS and PON1 activity are unreliable in assessing antioxidant protection.

Keywords: Antioxidants; Infant, premature; Oxidative stress; Reactive oxygen species; Retinopathy of prematurity.

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Figures

Fig. 1
Fig. 1
Length of ventilation in premature infants with and without retinopathy of prematurity (ROP). *p<0.05 ROP+ vs. ROP-
See this image and copyright information in PMC

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