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Case Reports
. 2018 Sep;57(3):581-587.
doi: 10.20471/acc.2018.57.03.23.

MULTIFOCAL MOTOR NEUROPATHY: CASE REPORTS

Edin Jusufović  1 , Osman Sinanović  1 , Sanela Zukić  1 , Adnan Burina  1 , Zlatka Džinić Jusufović  1 , Alma Šakić  1
Affiliations
Case Reports

MULTIFOCAL MOTOR NEUROPATHY: CASE REPORTS

Edin Jusufović et al. Acta Clin Croat. 2018 Sep.

Abstract

- Multifocal motor neuropathy (MMN) is a chronic demyelinating neuropathy mainly characterized by multifocal distribution; affecting only motor nerve fibers of two or more peripheral nerves, with the absence of symptoms and signs of upper motor neuron; chronic, sometimes cascading progressive course; demyelination with partial block of motor conduction; immune-mediated pathogenesis and good response to intravenous immunoglobulin treatment (IVIG). The diagnosis of MMN is based on clinical, laboratory and electrophysiological characteristics. Steroids are ineffective in MMN and may lead to worsening of the disease. Similarly, therapeutic plasma exchange is negligibly effective in this neuropathy. However, more than 80% of patients with MMN experience improvement after IVIG. We present our three cases of MMN with positive response to IVIG.

Keywords: Demyelinating diseases; Immunoglobulins, intravenous; Motor neurons; Peripheral nerves; Polyneuropathies.

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Figures

Fig. 1
Fig. 1
Left sciatic nerve (n. tibialis), plurisegmental analysis of motor conduction velocity (partial conduction block).
Fig. 2
Fig. 2
Left deep peroneal nerve (partial conduction block).
Fig. 3
Fig. 3
Left deep peroneal nerve (conduction block).
See this image and copyright information in PMC

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