Serpentine supravenous hyperpigmentation related to carboplatin and vinorelbine chemotherapy: A case report

Abstract

Serpentine supravenous hyperpigmentation (SSH) is a unique type of chemotherapy-associated drug eruption, characterized by hyperpigmentation along the superficial venous network. Histopathology reveals an increase in melanin production without destruction of basal cells of the epidermis or dermal inflammatory infiltrate. Herein, we describe a patient who developed SSH after repeated intravenous infusions with carboplatin and vinorelbine; two medications that have been uncommonly reported in association with SSH previously.

Keywords: carboplatin; chemotherapeutic agent; serpentine supravenous hyperpigmentation.