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Comment
. 2019 Jun;25(6):879-882.
doi: 10.1038/s41591-019-0482-7.

Combining checkpoint inhibition and targeted therapy in melanoma

Affiliations
Comment

Combining checkpoint inhibition and targeted therapy in melanoma

Elisa A Rozeman et al. Nat Med. 2019 Jun.
No abstract available

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Comment on

  • Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients.
    Sullivan RJ, Hamid O, Gonzalez R, Infante JR, Patel MR, Hodi FS, Lewis KD, Tawbi HA, Hernandez G, Wongchenko MJ, Chang Y, Roberts L, Ballinger M, Yan Y, Cha E, Hwu P. Sullivan RJ, et al. Nat Med. 2019 Jun;25(6):929-935. doi: 10.1038/s41591-019-0474-7. Epub 2019 Jun 6. Nat Med. 2019. PMID: 31171876 Clinical Trial.
  • Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma.
    Ascierto PA, Ferrucci PF, Fisher R, Del Vecchio M, Atkinson V, Schmidt H, Schachter J, Queirolo P, Long GV, Di Giacomo AM, Svane IM, Lotem M, Bar-Sela G, Couture F, Mookerjee B, Ghori R, Ibrahim N, Moreno BH, Ribas A. Ascierto PA, et al. Nat Med. 2019 Jun;25(6):941-946. doi: 10.1038/s41591-019-0448-9. Epub 2019 Jun 6. Nat Med. 2019. PMID: 31171878 Clinical Trial.
  • Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma.
    Ribas A, Lawrence D, Atkinson V, Agarwal S, Miller WH Jr, Carlino MS, Fisher R, Long GV, Hodi FS, Tsoi J, Grasso CS, Mookerjee B, Zhao Q, Ghori R, Moreno BH, Ibrahim N, Hamid O. Ribas A, et al. Nat Med. 2019 Jun;25(6):936-940. doi: 10.1038/s41591-019-0476-5. Epub 2019 Jun 6. Nat Med. 2019. PMID: 31171879 Free PMC article. Clinical Trial.

References

    1. Long, G. V. et al. J. Clin. Oncol. 36, 667–673 (2018). - DOI
    1. Larkin, J. et al. N. Engl. J. Med. 371, 1867–1876 (2014). - DOI
    1. Long, G. V. et al. Am. J. Clin. Oncol. 36, 9503–9503 (2018). - DOI
    1. Hodi, F. S. et al. Lancet Oncol. 19, 1480–1492 (2018). - DOI
    1. Ribas, A. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0476-5 (2019). - DOI

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