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. 2019 May;4(1):27-34.
doi: 10.1159/000499199. Epub 2019 Apr 17.

Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis

Harit Goverdhan Kothari  1 , Sudhir Jagdishprasad Gupta  1 , Nitin Rangrao Gaikwad  1
Affiliations

Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis

Harit Goverdhan Kothari et al. Inflamm Intest Dis. 2019 May.

Abstract

Background: Ulcerative colitis (UC) is characterized by chronic relapsing-remitting inflammation of the gastrointestinal tract. The chronic inflammatory process may predispose to atherosclerosis. The aim of the study was to assess the carotid intima-media thickness (CIMT) and its relation to subclinical atherosclerosis and to follow up cardiovascular complications in patients with UC.

Methods: 83 patients with proven UC in remission were enrolled in the study. 42 age- and sex-matched healthy controls were taken. Patients with known risk factors for atherosclerosis were excluded from the study. Baseline blood investigations along with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fasting lipid profile were done. CIMT was measured using B-mode Doppler imaging study.

Results: The mean age of the UC patients was 37.06 ± 14.87 years. Left-sided colitis (45.8%) was the commonest type of presentation according to the extent of the disease. Mean CIMT (0.55 ± 0.17) was significantly higher in UC patients when compared to mean CIMT (0.46 ± 0.13) in the control group (p = 0.002). In Pearson correlation analysis, age, ESR, and CRP were positive and significantly correlated with CIMT. Multiple linear regression analysis (R2 = 0.18, p = 0.0026) revealed that age and CRP were significant independent predictors of mean CIMT. On following up for 6 months, 4 patients with UC had complications in the form of venous thrombosis.

Conclusion: CIMT is a simple, noninvasive, reliable and objective auxiliary vascular parameter of structural alteration in UC patients.

Keywords: Atherosclerosis; Cardiovascular complications; Carotid intima-media thickness; Endothelial dysfunction; Ulcerative colitis.

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Figures

Fig. 1
Fig. 1
Ultrasonographic view of the common carotid artery (CCA). CIMT measurements done in the far wall of the CCA.
Fig. 2
Fig. 2
Comparison of mean CIMT in UC patients and controls.
Fig. 3
Fig. 3
Positive correlation between mean CIMT and CRP.
See this image and copyright information in PMC

References

    1. Hatoum OA, Binion DG, Contribution to Pathogenesis and Clinical Pathology The vasculature and inflammatory bowel disease: contribution to pathogenesis and clinical pathology. Inflamm Bowel Dis. 2005 Mar;11((3)):304–13. - PubMed
    1. Pathan F, Negishi K. Prediction of cardiovascular outcomes by imaging coronary atherosclerosis. Cardiovasc Diagn Ther. 2016 Aug;6((4)):322–39. - PMC - PubMed
    1. Van Doornum S, McColl G, Wicks IP. Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis? Arthritis Rheum. 2002 Apr;46((4)):862–73. - PubMed
    1. Selzer F, Sutton-Tyrrell K, Fitzgerald SG, Pratt JE, Tracy RP, Kuller LH, et al. Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus. Arthritis Rheum. 2004 Jan;50((1)):151–9. - PubMed
    1. Libby P, Ridker PM, Hansson GK, Leducq Transatlantic Network on Atherothrombosis Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009 Dec;54((23)):2129–38. - PMC - PubMed