Less iron improves MDS haematopoiesis
- PMID: 31172507
- DOI: 10.1111/bjh.16012
Less iron improves MDS haematopoiesis
Keywords: iron overload; lower-risk myelodysplastic syndromes; transfusion-related iron overload.
Comment on
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Deferasirox reduces oxidative DNA damage in bone marrow cells from myelodysplastic patients and improves their differentiation capacity.Br J Haematol. 2019 Oct;187(1):93-104. doi: 10.1111/bjh.16013. Epub 2019 Jun 6. Br J Haematol. 2019. PMID: 31172513 Clinical Trial.
References
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- Angelucci, E., Li, J., Greenberg, P.L., Depei, W., Hou, M., Montaño Figueroa, E., Rodriguez, G., Dong, X., Ghosh, J., Bornstein, O. & Garcia-Manero, G. (2018) Safety and efficacy, including event-free survival, of deferasirox versus placebo in iron-overloaded patients with low- and int-1-risk myelodysplastic syndromes (MDS): outcomes from the randomized, double-blind telesto study. Blood, 132, 234-234.
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- Fabiani, E., Calabrese, C., Niscola, P., Balleari, E., Molteni, A., Finelli, C., Falconi, G., Fenu, S., Fianchi, L., Criscuolo, M., Salvi, F., Lavorgna, S., Buccisano, F., Maurillo, L., Lo Coco, F., Cilloni, D. & Voso, M.T. (2019) Mutational profile and haematological response to iron chelation in myelodysplastic syndromes (MDS). British Journal of Haematology, 185, 954-957. https://doi.org/10.1111/bjh.15655.
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- Gattermann, N. (2008) Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload. International journal of hematology, 88, 24-29.
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- Gattermann, N., Finelli, C., Della Porta, M., Fenaux, P., Stadler, M., Guerci-Bresler, A., Schmid, M., Taylor, K., Vassilieff, D., Habr, D., Marcellari, A., Roubert, B. & Rose, C. (2012) Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes. Haematologica, 97, 1364-1371.
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