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. 2019 Jun 6;24(6):837-838.
doi: 10.1016/j.stem.2019.05.007.

Breakthrough Moments: Yoshiki Sasai's Discoveries in the Third Dimension

Jessica Mariani  1 , Flora M Vaccarino  2
Affiliations

Breakthrough Moments: Yoshiki Sasai's Discoveries in the Third Dimension

Jessica Mariani et al. Cell Stem Cell. .

Abstract

Yoshiki Sasai pioneered the organoid field with his idea of mimicking embryonic development in 3D. We shine a spotlight on his seminal work describing how the innate ability of embryonic stem cells to self-organize into layers and grow in a polarized fashion fosters their appropriate differentiation and response to morphogens.

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References

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