Tissue-Engineering the Intestine: The Trials before the Trials

Hans Clevers¹, Ryan K Conder², Vivian S W Li³, Matthias P Lutolf⁴, Ludovic Vallier⁵, Sarah Chan⁶, Tracy C Grikscheit⁷, Kim B Jensen⁸, Paolo De Coppi⁹

Affiliations

¹ Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, the Netherlands; Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands.
² STEMCELL Technologies, Vancouver, BC, Canada.
³ Stem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
⁴ Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Institute of Chemical Sciences and Engineering, School of Basic Science, EPFL, Lausanne, Switzerland.
⁵ Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK.
⁶ Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Nine Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK.
⁷ Developmental Biology and Regenerative Medicine Program, The Saban Research Institute at Children's Hospital Los Angeles, Los Angeles, CA, USA; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck Medical School, University of Southern California, Los Angeles, CA, USA.
⁸ Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen N, Denmark; Novo Nordisk Foundation Center for Stem Cell Biology, DanStem, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: kim.jensen@bric.ku.dk.
⁹ Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, UK; Stem Cells & Regenerative Medicine Section, NIHR Biomedical Research Center, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: paolo.decoppi@gosh.nhs.uk.

PMID: 31173715
DOI: 10.1016/j.stem.2019.04.018

Tissue-Engineering the Intestine: The Trials before the Trials

Hans Clevers et al. Cell Stem Cell. 2019.

. 2019 Jun 6;24(6):855-859.

doi: 10.1016/j.stem.2019.04.018.

Authors

Hans Clevers¹, Ryan K Conder², Vivian S W Li³, Matthias P Lutolf⁴, Ludovic Vallier⁵, Sarah Chan⁶, Tracy C Grikscheit⁷, Kim B Jensen⁸, Paolo De Coppi⁹

Affiliations

¹ Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, the Netherlands; Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands.
² STEMCELL Technologies, Vancouver, BC, Canada.
³ Stem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
⁴ Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Institute of Chemical Sciences and Engineering, School of Basic Science, EPFL, Lausanne, Switzerland.
⁵ Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK.
⁶ Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Nine Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK.
⁷ Developmental Biology and Regenerative Medicine Program, The Saban Research Institute at Children's Hospital Los Angeles, Los Angeles, CA, USA; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck Medical School, University of Southern California, Los Angeles, CA, USA.
⁸ Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen N, Denmark; Novo Nordisk Foundation Center for Stem Cell Biology, DanStem, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: kim.jensen@bric.ku.dk.
⁹ Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, UK; Stem Cells & Regenerative Medicine Section, NIHR Biomedical Research Center, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: paolo.decoppi@gosh.nhs.uk.

PMID: 31173715
DOI: 10.1016/j.stem.2019.04.018

Abstract

Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account cell source, scaffold choice, and design strategy for achieving proper assembly and function.

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Tissue-Engineering the Intestine: The Trials before the Trials

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Tissue-Engineering the Intestine: The Trials before the Trials

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Abstract

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