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. 2019 Jun 6;16(11):2025.
doi: 10.3390/ijerph16112025.

Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents

Roberto Bono  1 , Valeria Bellisario  2 , Roberta Tassinari  3 , Giulia Squillacioti  4 , Tilde Manetta  5 , Massimiliano Bugiani  6 , Enrica Migliore  7 , Pavilio Piccioni  8
Affiliations

Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents

Roberto Bono et al. Int J Environ Res Public Health. .

Abstract

Objectives: The purpose of this study was to investigate bisphenol A (BPA) and its role in the induction of oxidative stress and confirm the same for tobacco smoke.

Methods: A total of 223 young, healthy students (7-19 years old) were recruited in Chivasso, Italy. A spot of urine of each subject was analyzed to quantify BPA, cotinine, and 15F2t-isoprostane.

Results: BPA showed a slight increase of concentration proportional with increasing age, even though the 11-14 years age group had slightly lower results, inducing a V-shape. The same trend was observed for 15F2t-isoprostane and cotinine. The result of piecewise linear robust regression shows a break point of the effect of BPA on 15F2t-isoprostane at 6 ng/mg CREA (p < 0.001). At higher levels, 15F2t-isoprostane shows an exponential increase by more than threefold for each one-log unit of BPA. An increase of oxidative stress due to BPA was observed, but only from 6 ng/mg of CREA up. Passive tobacco smoke is also able to induce an increase in oxidative stress.

Conclusion: Prevention against BPA and passive tobacco smoke represents an important tool for promoting the highest health standard.

Keywords: BPA; adolescents; oxidative stress; passive tobacco smoke; public health.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Piecewise linear robust regression of the relation of log glucuronic acid of bisphenol A (GlcA–BPA) on log (ng 15F2t-IsoP/mg CREA)—(break point at BPA = 6 ng/mg creatinine (CREA), 95% CI: 4.5—7.5). Exp (1.79) = 6.
Figure 2
Figure 2
Margins plot of the relation between log 15F2t–IsoP and age classes.
See this image and copyright information in PMC

References

    1. Srivastava S., Gupta P., Chandolia A., Alam I. Bisphenol A: A threat to human health? J. Environ. Health. 2015;77:20–26. - PubMed
    1. Mielke H., Gundert-Remy U. Bisphenol A levels in blood depend on age and exposure. Toxicol. Lett. 2009;190:32–40. doi: 10.1016/j.toxlet.2009.06.861. - DOI - PubMed
    1. Lakind J.S., Naiman D.Q. Daily intake of bisphenol A and potential sources of exposure: 2005–2006 National Health and Nutrition Examination Survey. J. Exp. Sci. Environ. Epidemiol. 2011;21:272–279. doi: 10.1038/jes.2010.9. - DOI - PMC - PubMed
    1. Talsness C.E., Andrade A.J.M., Kuriyama S.N., Taylor J.A., vom Saal F.S. Components of plastic: Experimental studies in animals and relevance for human health. Philos. Trans. R Soc. Lond. B Biol. Sci. 2009;364:2079–2096. doi: 10.1098/rstb.2008.0281. - DOI - PMC - PubMed
    1. Goodman J.E., McConnell E.E., Sipes I.G., Witorsch R.J., Slayton T.M., Yu C.J., Lewis A.S., Rhomberg L.R. An updated weight of the evidence evaluation of reproductive and developmental effects of low doses of bisphenol A. Crit. Rev. Toxicol. 2006;36:387–457. doi: 10.1080/10408440600758317. - DOI - PubMed