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Review
. 2019 May;5(5):268-271.
doi: 10.1016/j.trecan.2019.03.001. Epub 2019 Apr 16.

DUX4 Pathological Expression: Causes and Consequences in Cancer

Carla Dib  1 , Vlada Zakharova  2 , Ekaterina Popova  3 , Ekaterina Kiseleva  4 , Boris Chernyak  3 , Marc Lipinski  1 , Yegor S Vassetzky  5
Affiliations
Review

DUX4 Pathological Expression: Causes and Consequences in Cancer

Carla Dib et al. Trends Cancer. 2019 May.

Abstract

DUX4, a double homeobox transcription factor, has been mostly studied in facioscapulohumeral dystrophy (FSHD), a pathology linked to a deletion of subtelomeric repeats on chromosome 4q. More recently, however, the gene has been associated with various sarcomas and haematological malignancies. Drugs developed for FSHD could be tested on cancer cells to develop efficient treatment strategies for both pathologies.

Keywords: DUX4; FSHD; leukaemia; sarcoma.

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