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Comment
. 2019 Sep;44(9):731-733.
doi: 10.1016/j.tibs.2019.05.003. Epub 2019 Jun 5.

Picky Eating at the ER-phagy Buffet

Simon Wilkinson  1
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Picky Eating at the ER-phagy Buffet

Simon Wilkinson. Trends Biochem Sci. 2019 Sep.

Abstract

The degradation of the endoplasmic reticulum (ER) by autophagy (ER-phagy) regulates proteostasis. Two studies (An et al., Mol. Cell, 2019; Chino et al., Mol. Cell, 2019) have uncovered a new ER-phagy molecule, TEX264, yielding insight into how ER is packaged for degradation, and have illuminated the extent of redundancy between different ER-phagy 'pathways' in remodelling the ER proteome.

Keywords: CCPG1; FAM134B; LIR; TEX264.

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