Viruses of hemorrhagic fever with renal syndrome (HFRS) grouped by immunoprecipitation and hemagglutination inhibition

Abstract

Nine viruses antigenically related to Hantaan virus that were isolated from various rodents in several countries and from a patient were examined by immunoprecipitation and by hemagglutination inhibition (HI). The immunoprecipitation tests were done with a monoclonal antibody that reacted with glycoprotein G2 and an antibody against a nucleocapsid protein. The viruses were classified into four subtypes on the basis of the molecular weights of their precipitated polypeptides and the pattern of results of the HI tests.