Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Fall;31(4):392-396.
doi: 10.1176/appi.neuropsych.19010017. Epub 2019 Jun 10.

An Opioid-Related Amnestic Syndrome With Persistent Effects on Hippocampal Structure and Function

P Monroe Butler  1 , Jed A Barash  1 , Kaitlin B Casaletto  1 , Devyn L Cotter  1 , Renaud La Joie  1 , Michael D Geschwind  1 , Howie J Rosen  1 , Joel H Kramer  1 , Bruce L Miller  1
Affiliations
Case Reports

An Opioid-Related Amnestic Syndrome With Persistent Effects on Hippocampal Structure and Function

P Monroe Butler et al. J Neuropsychiatry Clin Neurosci. 2019 Fall.
No abstract available

Keywords: Anterograde Amnesia; Hippocampus; Opioids.

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.. Acute neuroimaging with computerized tomography (CT) and MRI sequences in a patient with opioid-related acute amnestic syndromea
a DWI = diffusion-weighted imaging.
FIGURE 2.
FIGURE 2.. Pre- and postmorbid MRI of the hippocampi in a patient with opioid-related acute amnestic syndromea
a CA=cornu ammonis, DG=dentate gyrus, SUB=subiculum. Volumetric units are in milliliters (mL). The total intracranial and total gray matter volumes premorbid versus postmorbid differed by approximately 1% (1745.5589 mL, 1764.6615 mL, 837.5098 mL, and 848.7063 mL, respectively).
FIGURE 3.
FIGURE 3.. Three-dimensional construction of pre- and postmorbid hippocampal imaging in a patient with opioid-related acute amnestic syndrome
See this image and copyright information in PMC

References

    1. Barash JA, Somerville N, DeMaria A Jr: Cluster of an unusual amnestic syndrome–Massachusetts, 2012–2016. MMWR Morb Mortal Wkly Rep 2017; 66:76–79 - PMC - PubMed
    1. Barash JA, Ganetsky M, Boyle KL, et al.: Acute amnestic syndrome associated with fentanyl overdose. N Engl J Med 2018; 378: 1157–1158 - PubMed
    1. Small JE, Butler PM, Zabar Y, et al.: Complete, bilateral hippocampal ischemia: a case series. Neurocase 2016; 22:411–415 - PubMed
    1. Duru UB, Pawar G, Barash JA, et al.: An unusual amnestic syndrome associated with combined fentanyl and cocaine use. Ann Intern Med 2018; 168:747–748 - PubMed
    1. Hedegaard H, Bastian BA, Trinidad JP, et al.: Drugs most frequently involved in drug overdose deaths: United States, 2011–2016. Natl Vital Stat Rep 2018; 67:1–14 - PubMed

Publication types

Substances