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. 2019 Aug;42(8):514-517.
doi: 10.1016/j.tins.2019.05.007. Epub 2019 Jun 6.

A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu  1 , Kimberly H Cox  1 , Joseph S Takahashi  2
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A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu et al. Trends Neurosci. 2019 Aug.

Abstract

Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

Keywords: Drosophila; NADPH; redox state; sleep switch.

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