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. 2019 May 30:2:2398212818799271.
doi: 10.1177/2398212818799271. Epub 2018 Oct 12.

The genetics of neuropsychiatric disorders

Nicholas J Bray  1 , Michael C O'Donovan  1
Affiliations

The genetics of neuropsychiatric disorders

Nicholas J Bray et al. Brain Neurosci Adv. .

Abstract

Neuropsychiatric disorders are complex conditions with poorly defined neurobiological bases. In recent years, there have been significant advances in our understanding of the genetic architecture of these conditions and the genetic loci involved. This review article describes historical attempts to identify susceptibility genes for neuropsychiatric disorders, recent progress through genome-wide association studies, copy number variation analyses and exome sequencing, and how these insights can inform the neuroscientific investigation of these conditions.

Keywords: CNV; GWAS; Psychiatric disorder; association; attention deficit hyperactivity disorder; bipolar disorder; exome sequencing; genetic; linkage; major depressive disorder; pathway analysis; schizophrenia.

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Conflict of interest statement

Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

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